RESEARCH
F
Soil-to-Gut
기후변화 및 생태장벽 감염인자, 농약, 독소, 항생제내성 등은 공장식 농식품생산 시스템 상에서 건강을 위협하는 다양한 리스크를 유발. 농업생태 노출의 생체통합분석을 통해 토양-작물-인간의 지속가능 원헬스 푸드시스템 회복 연구
MucoExposome
환경 노출의 최전선인 점막장벽은 점막 면역시스템의 핵심적 인식 영역이다. 이들이 환경독성인자, 마이크로바이오타, 천연물 등 생물 화학적 요인과 숙주요인과의 상호작용을 이해하여 먹거리 연계 점막질환 및 신약 리간드 개발
RiboNetwork
점막 환경 스트레스의 세포 감지자로서 리보솜은 통합스트레스 반응(ISR)의 핵심적 세포 네트워크 기구이다. 특히 마이크로바이옴 및 미생물 노출 리보솜 스트레스에 의한 ISR 네트워크 교란과 항상성 기재규명을 통한 병태-항상성 연구
Selected articles All others in Google Scholar
Gut ribotoxic stress responses facilitate dyslipidemia via metabolic reprogramming: an environmental health prediction. Theranostics (2024), 14(3): 1289. 10.7150/thno.88586. * (JCR 4.2%): Chosen as the cover.
Stress-responsive Gdf15 counteracts renointestinal toxicity via autophagic and microbiota reprogramming. Communications Biology (2023), 6, 602. 10.1038/s42003-023-04965-1. * (JCR 8.2%)
Xenobiotic-induced ribosomal stress compromises dysbiotic gut barrier aging: A one health perspective. Redox Biology (2023). 102565.*
10.1016/j.redox.2022.102565 (JCR 9.0%)
Caveolin-1-ACE2 Axis Modulates Xenobiotic Metabolism-linked Chemoresistance in Ovarian Clear Cell Carcinoma. Cell Biology and Toxicology (2022), 10.1007/s10565-022-09733-1. * (JCR 5.9%)
MicroRNA target-based network predicts androgen receptor-linked mycotoxin stress. Ecotoxicology and Environmental Safety (2022), 230, 113130.*(JCR 7.5%) 10.1016/j.ecoenv.2021.113130
Antibiotic Exposure Aggravates Bacteroides-Linked Uremic Toxicity in the Gut-Kidney Axis. Frontiers in Immunology (2022). 13: 737536. * 10.3389/fimmu.2022.737536
Critical control point-based assessment and intervention of ochratoxin A risk in Angelicae Gigantis Radix production. Frontiers in Microbiology (2022)
13: 952628.* 10.3389/fmicb.2022.952628
Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation. Communications Biology (2021), 4, 543. * (JCR 8.2%)
Caveolar communication with xenobiotic-stalled ribosomes compromises gut barrier integrity. Communications Biology (2020). 3 (1): 270. * (JCR 8.1%) 10.1038/s42003-020-0994-1
Dynamic Malignant Wave of Ribosome-insulted Gut Niche via the Wnt-CTGF/CCN2 Circuit. iScience (2020). 23(5):101076. * 10.1016/j.isci.2020.101076
Nononcogenic restoration of the intestinal barrier by E. coli-delivered human EGF. JCI Insight (2019). 22;4(16). pii: 125166. * (JCR 10.1%) 10.1172/jci.insight.125166
Epithelial Cholesterol Deficiency Attenuates Human Antigen R-linked Pro-inflammatory Stimulation via an SREBP2-linked Circuit (2016). Journal of Biological Chemistry 291(47):24641-24656. *
Non-mutagenic Suppression of Enterocyte Ferroportin-1 by Chemical Ribosomal Inactivation via p38 MAPK-mediated Regulation: Evidences for Environmental Hemochromatosis (2016). Journal of Biological Chemistry 291(38):19858-72.*
Early Epithelial Restitution by NonsteroidalAnti-Inflammatory Drug–Activated Gene 1 Counteracts Intestinal Ulcerative Injuries (2016). J Immunology. 197(4):1415-24. *
Ribosome Inactivation Leads to Attenuation of Intestinal Polymeric Ig Receptor Expression via Differential Regulation of Human Antigen R (2016). J Immunology 197(3):847-58. *
Acquisition of Chemoresistance and Other Malignancy-related Features of Colorectal Cancer Cells Are Incremented by Ribosome-inactivating Stress (2016). Journal of Biological Chemistry 291(19):10173-83. *
Activating Transcription Factor3-mediated Chemo-intervention with Cancer Chemokines in a Non-Canonical Pathway under Endoplasmic Reticulum Stress (2014). Journal of Biological Chemistry 289(39):27118-33. *
Novel Regulatory Action of Ribosomal Inactivation on Epithelial Nod2-linked Pro-inflammatory Signals in Two Convergent ATF3-associated Pathways. (2013). Journal of Immunology 191(10), 5170-5180. *
Enteropathogenic Escherichia coli-induced macrophage inhibitory cytokine 1 mediates cancer cell survival: An in vitro implication of infection-linked tumor dissemination (2013). Oncogene 32 (41), 4960-4969. *
Suppressor of cytokine signaling 3 regulates Bcell activating factor in human enterocytes under ribosomal stress. (2013). Journal of Immunology 190(12), 6501-6510. *.
Two in-and-out modulation strategies for endoplasmic reticulum stress-linked gene expression of pro-apoptotic macrophage inhibitory cytokine 1 (2012). Journal of Biological Chemistry 287(24), 19841-55. *
Repression of Proxisome Proliferator-Activated Receptor gamma by Mucosal Ribotoxic Insult-activated C/EBP Homologous Protein (2010). J of Immunology 185 (9): 5522-5530. *
Endoplasmic Reticulum Stress-activated C/EBP Homologous Protein Enhances Nuclear factor-kappa B Signals via Repression of Proxisome Proliferator-Activated Receptor (2010). Journal of Biological Chemistry 285 (46): 35330-35339. *
