THE MOON LAB
Food Systems Analytics
RESEARCH
Soil-to-Gut
농식품사슬 전단계 및 공급망에서 기후변화, 농약, 독소, 항생제내성 등은 공장식 농식품생산 시스템 상에서 건강을 위협하는 다양한 리스크를 유발. 식품전단계 생체통합분석 통한 지속가능 푸드시스템 회복 연구
Muco
Exposome
푸드시스템 환경 노출 최전선인 점막장벽은 점막 면역시스템의 핵심적 인식 영역이다. 이들이 환경독성인자, 마이크로바이오타, 천연물 등 생물 화학적 요인과 숙주요인과의 상호작용을 이해하여 첨단예측 방법론 개발
BioValue Chains
환경 스트레스의 세포 감지자로서 통합스트레스 반응(ISR)의 핵심적 대응 기구이다. 특히 마이크로바이옴 및 미생물 노출 화학 스트레스에 의한 ISR 네트워크 교란과 만성질환 병태발현경로 및 생애 전주기 분석 예측 연구
Bioeconomy
환경-생산동식품-인간 건강성의 순환성 및 지속가능성을 기반으로 외부효과를 미시적 기반에서 정밀 예측 분석하여 거시적 경제 주체 개념의 도입과 지속가능한 원헬스 정책 결정을 위한 중개적 바이오경제학적 실증
Selected articles *corresponding author. All others in Google Scholar
The Gdf15-xenobiotic receptor axis shapes NK cell maladaptation predicting cold tumors under environmental stress. Signal Transduction and Targeted Therapy (2026). 11(1):219. doi: 10.1038/s41392-026-02690-9. * (IF 81.2, JCR 0.35%)
Unraveling the impacts of particulate plastics from agroecosystems to one health. Science of the Total Environment. (2025). 1003:180649. doi: 10.1016/j.scitotenv.2025.180649.* (IF 8.0, JCR 8.5%)
Ribosomal proteins mediate non-canonical regulation of gut inflammatory signature by crop contaminant deoxynivalenol. Ecotoxicology and Environmental Safety (2025). 289:117645. doi:10.1016/j.ecoenv.2024.117645.* (JCR 7.5%)
Gut ribotoxic stress responses facilitate dyslipidemia via metabolic reprogramming: an environmental health prediction. Theranostics (2024), 14(3): 1289. 10.7150/thno.88586. * (IF 14.9, JCR 4.2%): Chosen as the cover.
Stress-responsive Gdf15 counteracts renointestinal toxicity via autophagic and microbiota reprogramming. Communications Biology (2023), 6, 602. 10.1038/s42003-023-04965-1. * (JCR 8.2%)
Xenobiotic-induced ribosomal stress compromises dysbiotic gut barrier aging: A one health perspective. Redox Biology (2023). 102565.*
10.1016/j.redox.2022.102565 (IF 16.2 JCR 3.8%)
Caveolin-1-ACE2 Axis Modulates Xenobiotic Metabolism-linked Chemoresistance in Ovarian Clear Cell Carcinoma. Cell Biology and Toxicology (2022), 10.1007/s10565-022-09733-1. * (JCR 5.9%)
MicroRNA target-based network predicts androgen receptor-linked mycotoxin stress. Ecotoxicology and Environmental Safety (2022), 230, 113130.*(JCR 7.5%) 10.1016/j.ecoenv.2021.113130
Antibiotic Exposure Aggravates Bacteroides-Linked Uremic Toxicity in the Gut-Kidney Axis. Frontiers in Immunology (2022). 13: 737536. * 10.3389/fimmu.2022.737536
Critical control point-based assessment and intervention of ochratoxin A risk in Angelicae Gigantis Radix production. Frontiers in Microbiology (2022)
13: 952628.* 10.3389/fmicb.2022.952628
Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation. Communications Biology (2021), 4, 543. * (JCR 8.2%)
Caveolar communication with xenobiotic-stalled ribosomes compromises gut barrier integrity. Communications Biology (2020). 3 (1): 270. * (JCR 8.1%) 10.1038/s42003-020-0994-1
Dynamic Malignant Wave of Ribosome-insulted Gut Niche via the Wnt-CTGF/CCN2 Circuit. iScience (2020). 23(5):101076. * 10.1016/j.isci.2020.101076
Nononcogenic restoration of the intestinal barrier by E. coli-delivered human EGF. JCI Insight (2019). 22;4(16). pii: 125166. * (JCR 10.1%) 10.1172/jci.insight.125166
Epithelial Cholesterol Deficiency Attenuates Human Antigen R-linked Pro-inflammatory Stimulation via an SREBP2-linked Circuit (2016). Journal of Biological Chemistry 291(47):24641-24656. *
Non-mutagenic Suppression of Enterocyte Ferroportin-1 by Chemical Ribosomal Inactivation via p38 MAPK-mediated Regulation: Evidences for Environmental Hemochromatosis (2016). Journal of Biological Chemistry 291(38):19858-72.*
Early Epithelial Restitution by NonsteroidalAnti-Inflammatory Drug–Activated Gene 1 Counteracts Intestinal Ulcerative Injuries (2016). J Immunology. 197(4):1415-24. *
Ribosome Inactivation Leads to Attenuation of Intestinal Polymeric Ig Receptor Expression via Differential Regulation of Human Antigen R (2016). J Immunology 197(3):847-58. *
Acquisition of Chemoresistance and Other Malignancy-related Features of Colorectal Cancer Cells Are Incremented by Ribosome-inactivating Stress (2016). Journal of Biological Chemistry 291(19):10173-83. *
Activating Transcription Factor3-mediated Chemo-intervention with Cancer Chemokines in a Non-Canonical Pathway under Endoplasmic Reticulum Stress (2014). Journal of Biological Chemistry 289(39):27118-33. *
Novel Regulatory Action of Ribosomal Inactivation on Epithelial Nod2-linked Pro-inflammatory Signals in Two Convergent ATF3-associated Pathways. (2013). Journal of Immunology 191(10), 5170-5180. *
Enteropathogenic Escherichia coli-induced macrophage inhibitory cytokine 1 mediates cancer cell survival: An in vitro implication of infection-linked tumor dissemination (2013). Oncogene 32 (41), 4960-4969. *
Suppressor of cytokine signaling 3 regulates Bcell activating factor in human enterocytes under ribosomal stress. (2013). Journal of Immunology 190(12), 6501-6510. *.
Two in-and-out modulation strategies for endoplasmic reticulum stress-linked gene expression of pro-apoptotic macrophage inhibitory cytokine 1 (2012). Journal of Biological Chemistry 287(24), 19841-55. *
Repression of Proxisome Proliferator-Activated Receptor gamma by Mucosal Ribotoxic Insult-activated C/EBP Homologous Protein (2010). J of Immunology 185 (9): 5522-5530. *
Endoplasmic Reticulum Stress-activated C/EBP Homologous Protein Enhances Nuclear factor-kappa B Signals via Repression of Proxisome Proliferator-Activated Receptor (2010). Journal of Biological Chemistry 285 (46): 35330-35339. *
